Fischer’s versatility shines beyond The Office, with film roles in comedies like Blades of Glory (2007) opposite Will Ferrell, Walk Hard: The Dewey Cox Story (2007), Hall Pass (2011), and indie gems such as The Giant Mechanical Man (2012), directed by her husband Lee Kirk. She has returned to her theater roots with stage work, including Off-Broadway productions like Reasons to Be Happy and the world premiere of Steve Martin’s Meteor Shower, as well as a 2025 performance in Ashland Avenue at Chicago’s Goodman Theatre as part of their centennial season. On television, she appeared in series like You, Me and the Apocalypse, Splitting Up Together (2018–2019), The Guest Book, and more recently voiced characters in projects like Bluey Book Reads. In 2024, she faced a personal challenge with an aggressive breast cancer diagnosis (announced publicly in emotional posts), completing treatment and emerging cancer-free by late 2024/early 2025, sharing updates on her recovery, hair regrowth, and gratitude for support from family. Married to filmmaker Lee Kirk since 2010 (after a prior marriage to James Gunn from 2000–2008), she is a mother to two children—son Weston Lee (born 2011) and daughter Harper Marie (born 2014)—and co-hosts the popular Office Ladies podcast with Angela Kinsey, where she reflects on the show, reunites with castmates (including 2025 meetups with Rainn Wilson), and explores new creative paths. Fischer’s warm presence, sharp humor, and resilience—evident in her advocacy, family focus, and continued acting—keep her as an enduring, heartfelt figure in entertainment, with fresh opportunities in film, TV, and stage on the horizon.